T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM
family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and …

Ongoing research has revealed that the existence of cancer stem cells (CSCs) is one of the
biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor …

Immunotherapy is being increasingly recognized as a key therapeutic modality to treat
cancer and represents one of the most exciting treatments for the disease. Fighting cancer …

Tim-3 is a T helper type 1 (TH1)–specific cell surface molecule that seems to regulate TH1
responses and the induction of peripheral tolerance. However, the identity of the Tim-3 …

▪ Abstract Multiple sclerosis (MS) develops in young adults with a complex predisposing
genetic trait and probably requires an inciting environmental insult such as a viral infection …

Natural killer (NK) cells are innate lymphocytes that play an important role against viral
infections and cancer. This effect is achieved through a complex mosaic of inhibitory and …

Abstract Kidney injury molecule 1 (KIM-1) is a type I membrane protein, comprising an
extracellular portion and a cytoplasmic portion. It is also named as HAVCR1 (Hepatitis A …

The TIM (T cell/transmembrane, immunoglobulin, and mucin) gene family plays a critical role
in regulating immune responses, including allergy, asthma, transplant tolerance …

Along with microglia and monocyte-derived macrophages, macrophages in the perivascular
space, choroid plexus, and meninges are the principal effector cells in neuroinflammatory …

CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by
numerous pathways, including the negative immune receptor Tim-3. We found that Tim-3 is …