BACKGROUND As the world population ages, chronic diseases such as diabetes,
cardiovascular disease, cancer, and neurodegeneration become ever more prevalent …

Putrescine, spermine, and spermidine are the important polyamines (PAs), found in all living
organisms. PAs are formed by the decarboxylation of amino acids, and they facilitate cell …

Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

The presence of Akkermansia muciniphila (Akk) in the human gut is associated with good
health, leanness and fitness. Mouse experimentation has demonstrated positive effects for …

Age-dependent memory impairment is known to occur in several organisms, including
Drosophila, mouse and human. However, the fundamental cellular mechanisms that …

Several natural compounds found in health-related food items can inhibit acetyltransferases
as they induce autophagy. Here we show that this applies to anacardic acid, curcumin …

Polyamines are ubiquitous positively charged amines found in all organisms. These
molecules play a crucial role in many biological functions including cell growth, gene …

Arterial aging, characterized by stiffening of large elastic arteries and the development of
arterial endothelial dysfunction, increases cardiovascular disease (CVD) risk. We tested the …

Background: Spermidine, a naturally occurring polyamine, has recently emerged as
exhibiting anti-aging properties. Its supplementation increases lifespan and resistance to …

Polyamines have been shown to delay cellular and organismal aging and to provide
cardiovascular protection in humans. Because age-related cardiovascular dysfunction is …