Asthma is a globally significant non-communicable disease with major public health
consequences for both children and adults, including high morbidity, and mortality in severe …

Asthma is a chronic respiratory disease characterized by variable airflow obstruction,
bronchial hyperresponsiveness, and airway inflammation. Evidence suggests that air …

Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

The possibility that parental life experiences and environmental exposures influence mental
and physical health across generations is an important concept in biology and medicine …

The lung is one of the most important organs exposed to environmental agents. People
spend approximately 90% of their time indoors, and risks to health may thus be greater from …

Background Tobacco consumption is the largest avoidable health risk. Understanding
changes of smoking over time and across populations is crucial to implementing health …

Objectives To describe the methodological characteristics of mediation analyses (MAs)
reported in recent randomized controlled trials (RCTs) and to propose recommendations on …

Background Experimental studies suggest that exposures may impact respiratory health
across generations via epigenetic changes transmitted specifically through male germ cells …

Background The preconception period represents transgenerational opportunities to
optimize modifiable risk factors associated with both short and long-term adverse health …

It has become clear that early life (including in utero exposures) is a key window of
vulnerability during which environmental exposures can alter developmental trajectories …