Multidrug resistance (MDR) is a significant issue associated with the clinical application of
antibiotics. It is also challenging to discover and develop new antibiotics with novel …

As microbial resistance to drugs continues to rise at an alarming rate, finding new ways to
combat pathogens is an issue of utmost importance. Development of novel and specific …

Drug discovery, development and registration is an expensive and time-consuming process
associated with a high failure rate [Pessetto et al.(Mol Cancer Ther 12: 1299–1309, 2013) …

Infections caused by antibiotic-resistant bacteria are a rising public health threat and make
the identification of new antibiotics a priority. From a cell-based screen for bactericidal …

Traditional methods employed to discover new antibiotics are both a time-consuming and
financially-taxing venture. This has led researchers to mine existing libraries of clinical …

The reaction of gold reagents [HAuCl4• 3H2O],[AuCl (tht)], or cyclometalated gold (III)
precursor,[C^ NAuCl2] with chiral ((R, R)-(-)-2, 3-bis (t-butylmethylphosphino) quinoxaline) …

It is now well established that bacterial infections are often associated with biofilm
phenotypes that demonstrate increased resistance to common antimicrobials. Further, due …

Auranofin, an FDA-approved arthritis drug, has recently been repurposed as a potential
antimicrobial agent; it performed well against many Gram-positive bacteria, including …

Due to the so‐called “antibiotic resistance crisis” new antibacterial agents are urgently
sought to treat multidrug‐resistant pathogens. A group of gold‐or silver‐based complexes, of …

A series of gold (I) complexes with two N-heterocyclic carbene ligands (biscarbene gold
complexes) were prepared and evaluated for their effects against cancer cells and …