Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Epigenetic modifications of the nuclear genome, including DNA methylation, histone
modifications and non-coding RNA post-transcriptional regulation, are increasingly being …

Given the role of mitochondria in oxygen consumption, metabolism and cell death
regulation, alterations in mitochondrial function or dysregulation of cell death pathways …

Mitochondria from normal and cancerous cells represent a tale of two cities, wherein both
execute similar processes but with different cellular and molecular effects. Given the number …

In human beings, there is a∼ 16,569 bp circular mitochondrial DNA (mtDNA) encoding 22
tRNAs, 12S and 16S rRNAs, 13 polypeptides that constitute the central core of ETC/OxPhos …

Background The association between obesity and cardiovascular disease (CVD) is proven,
but why some adults with obesity develop CVD while others remain disease-free is poorly …

Methylation levels of the mitochondrial displacement loop (D-loop) region have been
reported to be altered in the brain and blood of Alzheimer's disease (AD) patients. Moreover …

Food nutrients and metabolic supply–demand dynamics constitute environmental factors
that interact with our genome influencing health and disease states. These gene …

Alzheimer's disease (AD) is the most common cause of dementia. Increasing evidence
shows that mitochondrial DNA (mtDNA) methylation plays an essential role in many …

The maintenance of the mitochondrial function is essential in preventing and counteracting
neurodegeneration. In particular, mitochondria of neuronal cells play a pivotal role in …