Safety of nanoparticles in medicine

J Wolfram, M Zhu, Y Yang, J Shen, E Gentile… - Current drug …, 2015 - ingentaconnect.com
Nanomedicine involves the use of nanoparticles for therapeutic and diagnostic purposes.
During the past two decades, a growing number of nanomedicines have received regulatory …

Advances in liposomal drug delivery to cancer: An overview

S Saraf, A Jain, A Tiwari, A Verma, PK Panda… - Journal of drug delivery …, 2020 - Elsevier
Liposomes are biodegradable and biocompatible lipid bilayer vesicles which are widely
exploited as preferred carriers for smart delivery of both hydrophobic as well as hydrophilic …

In Vivo Biomolecule Corona around Blood-Circulating, Clinically Used and Antibody-Targeted Lipid Bilayer Nanoscale Vesicles

M Hadjidemetriou, Z Al-Ahmady, M Mazza, RF Collins… - ACS …, 2015 - ACS Publications
The adsorption of proteins and their layering onto nanoparticle surfaces has been called the
“protein corona”. This dynamic process of protein adsorption has been extensively studied …

The human in vivo biomolecule corona onto PEGylated liposomes: a proof‐of‐concept clinical study

M Hadjidemetriou, S McAdam, G Garner… - Advanced …, 2019 - Wiley Online Library
The self‐assembled layered adsorption of proteins onto nanoparticle (NP) surfaces, once in
contact with biological fluids, is termed the “protein corona” and it is gradually seen as a …

Time-evolution of in vivo protein corona onto blood-circulating PEGylated liposomal doxorubicin (DOXIL) nanoparticles

M Hadjidemetriou, Z Al-Ahmady, K Kostarelos - Nanoscale, 2016 - pubs.rsc.org
Nanoparticles (NPs) are instantly modified once injected in the bloodstream because of their
interaction with the blood components. The spontaneous coating of NPs by proteins, once in …

[HTML][HTML] Surface modified multifunctional and stimuli responsive nanoparticles for drug targeting: current status and uses

PI Siafaka, N Üstündağ Okur, E Karavas… - International journal of …, 2016 - mdpi.com
Nanocarriers, due to their unique features, are of increased interest among researchers
working with pharmaceutical formulations. Polymeric nanoparticles and nanocapsules …

[HTML][HTML] LinTT1 peptide-functionalized liposomes for targeted breast cancer therapy

N d'Avanzo, G Torrieri, P Figueiredo, C Celia… - International journal of …, 2021 - Elsevier
Breast cancer, with around 2 million new cases in 2019, is the second most common cancer
worldwide and the second leading cause of cancer death among females. The aim of this …

The nano-plasma interface: Implications of the protein corona

J Wolfram, Y Yang, J Shen, A Moten, C Chen… - Colloids and Surfaces B …, 2014 - Elsevier
The interactions between nanoparticles and macromolecules in the blood plasma dictate the
biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of …

[HTML][HTML] In situ detection of the protein corona in complex environments

M Carril, D Padro, P Del Pino, C Carrillo-Carrion… - Nature …, 2017 - nature.com
Colloidal nanoparticles (NPs) are a versatile potential platform for in vivo nanomedicine.
Inside blood circulation, NPs may undergo drastic changes, such as by formation of a …

Spotlight on the protein corona of liposomes

N Onishchenko, D Tretiakova, E Vodovozova - Acta biomaterialia, 2021 - Elsevier
Although an established drug delivery platform, liposomes have not fulfilled their true
potential. In the body, interactions of liposomes are mediated by the layer of plasma proteins …