Recurrent pregnancy loss

E Dimitriadis, E Menkhorst, S Saito… - Nature reviews disease …, 2020 - nature.com
Recurrent pregnancy loss is a distressing pregnancy disorder experienced by~ 2.5% of
women trying to conceive. Recurrent pregnancy loss is defined as the failure of two or more …

Uterine glands: developmental biology and functional roles in pregnancy

AM Kelleher, FJ DeMayo, TE Spencer - Endocrine reviews, 2019 - academic.oup.com
All mammalian uteri contain glands in the endometrium that develop only or primarily after
birth. Gland development or adenogenesis in the postnatal uterus is intrinsically regulated …

[HTML][HTML] In situ delivery of apoptotic bodies derived from mesenchymal stem cells via a hyaluronic acid hydrogel: a therapy for intrauterine adhesions

L Xin, C Wei, X Tong, Y Dai, D Huang, J Chen, L Ma… - Bioactive materials, 2022 - Elsevier
Stem cell-based and stem cell-derived exosome-based therapies have shown promising
potential for endometrial regeneration and the clinical treatment of intrauterine adhesions …

Embryo‐uterine interaction coordinates mouse embryogenesis during implantation

V Bondarenko, M Nikolaev, D Kromm… - The EMBO …, 2023 - embopress.org
Embryo implantation into the uterus marks a key transition in mammalian development. In
mice, implantation is mediated by the trophoblast and is accompanied by a morphological …

Self-renewing endometrial epithelial organoids of the human uterus

HC Fitzgerald, P Dhakal, SK Behura… - Proceedings of the …, 2019 - National Acad Sciences
The human endometrium is essential in providing the site for implantation and maintaining
the growth and survival of the conceptus. An unreceptive endometrium and disrupted …

Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery

Y Cao, Z Li, W Jiang, Y Ling, H Kuang - Reproductive Biology and …, 2019 - Springer
Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian
reproduction due to their involvement in the onset of puberty and control of the hypothalamic …

Organoid systems to study the human female reproductive tract and pregnancy

L Alzamil, K Nikolakopoulou, MY Turco - Cell Death & Differentiation, 2021 - nature.com
Both the proper functioning of the female reproductive tract (FRT) and normal placental
development are essential for women's health, wellbeing, and pregnancy outcome. The …

FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation

YM Vasquez, X Wang, M Wetendorf, HL Franco… - PLoS …, 2018 - journals.plos.org
Successful embryo implantation requires a receptive endometrium. Poor uterine receptivity
can account for implantation failure in women who experience recurrent pregnancy loss or …

Three-dimensional culture models of human endometrium for studying trophoblast-endometrium interaction during implantation

X Li, SP Kodithuwakku, RWS Chan… - Reproductive Biology …, 2022 - Springer
During implantation, a symphony of interaction between the trophoblast originated from the
trophectoderm of the implanting blastocyst and the endometrium leads to a successful …

The human periconceptional maternal-embryonic space in health and disease

I Moreno, A Capalbo, A Mas… - Physiological …, 2023 - journals.physiology.org
Pregnancy is established during the periconceptional period as a continuum beginning with
blastocyst attachment to the endometrial epithelial surface followed by embryo invasion and …