The role of the maternal immune system in reproductive success in humans remains
controversial. Here we focus on the events that occur in the maternal decidua during the first …

As the COVID-19 pandemic continues into its third year, emerging data indicates increased
risks associated with SARS-CoV-2 infection during pregnancy, including pre-eclampsia …

The relationship between the human placenta—the extraembryonic organ made by the
fetus, and the decidua—the mucosal layer of the uterus, is essential to nurture and protect …

Stem cell-based embryo models offer unprecedented experimental tools for studying early
human development. The usefulness of embryo models hinges on their molecular, cellular …

Naive human pluripotent stem cells have the remarkable ability to self-organize into
blastocyst-like structures (" blastoids") that model lineage segregation in the pre …

SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19
during pregnancy to negative birth outcomes and placentitis. However, the …

The human placenta has a vital role in ensuring a successful pregnancy. Despite the
growing body of knowledge about its cellular compositions and functions, there has been …

Zika virus (ZIKV) infection during pregnancy threatens pregnancy and fetal health. However,
the infectivity and pathological effects of ZIKV on placental trophoblast progenitor cells in …

As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast
layer contributes to a successful pregnancy by secreting hormones necessary for …

With the advancement of human stem cell cultures and interest in understanding human
embryogenesis, human blastocyst-like structures, or human blastoids, are being developed …