[HTML][HTML] Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution
Skeletal muscle fibers express distinct gene programs during development and maturation,
but the underlying gene regulatory networks that confer stage-specific myofiber properties …
but the underlying gene regulatory networks that confer stage-specific myofiber properties …
[HTML][HTML] PROTAC-Based Protein Degradation as a Promising Strategy for Targeted Therapy in Sarcomas
C Mancarella, A Morrione, K Scotlandi - International Journal of …, 2023 - mdpi.com
Sarcomas are heterogeneous bone and soft tissue cancers representing the second most
common tumor type in children and adolescents. Histology and genetic profiling discovered …
common tumor type in children and adolescents. Histology and genetic profiling discovered …
[HTML][HTML] The effects of CypA on apoptosis: potential target for the treatment of diseases
L Chen, Z Zeng, H Luo, H Xiao, Y Zeng - Applied Microbiology and …, 2024 - Springer
Cyclophilin A (CypA), the first member of cyclophilins, is distributed extensively in eukaryotic
and prokaryotic cells, primarily localized in the cytoplasm. In addition to acting as an …
and prokaryotic cells, primarily localized in the cytoplasm. In addition to acting as an …
CD73 contributes to the pathogenesis of fusion-negative rhabdomyosarcoma through the purinergic signaling pathway
KC Hernandez, AM Shah, VA Lopez… - Proceedings of the …, 2024 - National Acad Sciences
Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children and
adolescents. Fusion-negative RMS (FN-RMS) accounts for more than 80% of all RMS cases …
adolescents. Fusion-negative RMS (FN-RMS) accounts for more than 80% of all RMS cases …
Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development
M Cui, S Bezprozvannaya, T Hao, A Elnwasany… - Developmental cell, 2023 - cell.com
Cardiomyocytes are highly metabolic cells responsible for generating the contractile force in
the heart. During fetal development and regeneration, these cells actively divide but lose …
the heart. During fetal development and regeneration, these cells actively divide but lose …
[HTML][HTML] Contemporary preclinical mouse models for pediatric rhabdomyosarcoma: from bedside to bench to bedside
I Martynov, L Dhaka, B Wilke, P Hoyer… - Frontiers in …, 2024 - frontiersin.org
Background Rhabdomyosarcoma (RMS) is the most common pediatric soft-tissue
malignancy, characterized by high clinicalopathological and molecular heterogeneity …
malignancy, characterized by high clinicalopathological and molecular heterogeneity …
Role of CD73 and the purinergic signaling pathway in the pathogenesis of fusion-negative rhabdomyosarcoma
A Fascì, S Deaglio - Purinergic Signalling, 2024 - Springer
Rhabdomyosarcoma (RMS) is a malignant soft tissue sarcoma mostly diagnosed in children
and young adults and often associated with a poor outcome [1]. Fusion-negative RMS (FN …
and young adults and often associated with a poor outcome [1]. Fusion-negative RMS (FN …