Hydroxypropyl methylcellulose (HPMC) is an important polymeric excipient. Its versatility in
terms of molecular weights and viscosity grades is the basis for its wide and successful …

Tableting by direct compression (DC) is one of the simplest and most cost-effective drug
manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and …

Naproxen is a common analgesic and antipyretic medication that is widely used around the
world. This medicine at high doses leads to liver and kidney necrosis in humans and …

Background Solid dispersion (SD) has been used conventionally as a successful technique
for improving the dissolution profile and bioavailability of poorly water-soluble drugs. The …

Since famotidine (FA) is prescribed for gastrointestinal diseases orodispersible tablets could
contribute to patients' compliance. Its bitter taste and poor compressibility pose formulation …

Paracetamol (PCT) and propyphenazone (PRP) are analgesic drugs that are often
combined in a single dosage form for enhanced pharmacological action. In this work, PCT …

The present study aims to use a natural protein silk fibroin (SF) to enhance solubility,
dissolution, tablettability, and subsequently, delivery of naproxen (NP) using a green …

Spray drying is a continuous manufacturing process that requires the use of a small number
of excipients and offers great flexibility to formulation scientists due to the easy operation …

Univerzita Karlova, Farmaceutická fakulta v Hradci Králové Katedra: Farmaceutické
technologie Školitel: doc. PharmDr. Jitka Mužíková, Ph. D. Konzultant: Mgr. Thao Tranová …

Tableting by direct compression (DC) is one of the simplest and most cost-effective drug
manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and …