Bone fracture followed by delayed or non-union typically requires bone graft intervention.
Autologous bone grafts remain the clinical “gold standard”. Recently, synthetic bone grafts …

Although biodegradable polymer coatings can impede corrosion of magnesium (Mg)-based
orthopedic implants, they are prone to excessive degradation and accidental scratching in …

Simvastatin is a lipid lowering drug whose beneficial role on bone metabolism was
discovered in 1999. Several in vivo studies evaluated its role on osteoporosis and fracture …

This study aims to formulate and optimize simvastatin loaded chitosan-tripolyphosphate
nanoparticles (SIM CS-TPP NPs) using ionic gelation method to provide a local delivery …

The Ligament Advanced Reinforcement System has recently been widely used as the
primary graft of choice in anterior cruciate ligament (ACL) reconstruction. But the biological …

Repairing critical-sized bone defects has been a major challenge for orthopedic surgeons in
the clinic. The generation of functioning bone tissue scaffolds using osteogenic induction …

A novel bone scaffold containing bioceramic and biopolymer materials with an
osteoinductive simvastatin molecule was developed to enhance bone regeneration. An …

A new hydrogel scaffold, containing both osteoconductive and osteoinductive properties,
was developed for enhanced bone regeneration. Simvastatin loaded Gelatin-nanofibrillar …

The harsh microenvironment of persistent inflammation and insufficient nutrient supply in
diabetic organism impedes severely the osteogenic differentiation. Current management on …

Polymer/bioceramic composite micro-particles have been used for bone regeneration in
order to address weak mechanical properties/bioactivity of polymers and to enable easy …