Rural communities in developing countries lack access to affordable, reliable, and
sustainable forms of energy, which are essential factors for improving living conditions …

The timely production of functional proteins is of critical importance for the biological activity
of cells. To reach the functional state, newly synthesized polypeptides have to become …

INTRODUCTION Most newly synthesized proteins associate into macromolecular
complexes to become functional. Complex formation requires that subunits find each other …

During the co-translational assembly of protein complexes, a fully synthesized subunit
engages with the nascent chain of a newly synthesized interaction partner. Such events are …

Protein self-organization is a hallmark of biological systems. Although the physicochemical
principles governing protein–protein interactions have long been known, the principles by …

The faithful assembly of protein complexes in space and time is a hallmark of cellular
homeostasis. Complex assembly might be seeded already during translation, if interacting …

Protein complex assembly often occurs while subunits are being translated, resulting in
complexes whose subunits were translated from the same mRNA in an allele-specific …

Motivation Recombinant protein production is a widely used technique in the biotechnology
and biomedical industries, yet only a quarter of target proteins are soluble and can therefore …

Many large proteins suffer from slow or inefficient folding in vitro. It has long been known that
this problem can be alleviated in vivo if proteins start folding cotranslationally. However, the …

Protein aggregation propensity is a pervasive and seemingly inescapable property of
proteomes. Strikingly, a significant fraction of the proteome is supersaturated, meaning that …