The expression of mitochondrial genes is regulated in response to the metabolic needs of
different cell types, but the basic mechanisms underlying this process are still poorly …

Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times.
They have enjoyed over 30 years of clinical usage and become essential tools in the …

Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …

DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and
indispensable for cellular survival due to the numerous roles they play during DNA …

The remodelling of replication forks into four-way junctions following replication perturbation,
known as fork reversal, was hypothesized to promote DNA damage tolerance and repair …

Genome replication involves dealing with obstacles that can result from DNA damage but
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …

Breast cancer suppressor BRCA2 is critical for maintenance of genomic integrity and
resistance to agents that damage DNA or collapse replication forks, presumably through …

DNA topoisomerases are the magicians of the DNA world—by allowing DNA strands or
double helices to pass through each other, they can solve all of the topological problems of …

Aberrant DNA replication is a major source of the mutations and chromosome
rearrangements that are associated with pathological disorders. When replication is …

DNA topoisomerases are enzymes that disentangle the topological problems that arise in
double-stranded DNA. Many of these can be solved by the generation of either single or …