[HTML][HTML] Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing
K Chathuranga, A Weerawardhana… - … & Molecular Medicine, 2021 - nature.com
A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …
receptor (PRR)-initiated immune responses is required to achieve the most favorable …
Similarities and dissimilarities of COVID-19 and other coronavirus diseases
TS Fung, DX Liu - Annual review of microbiology, 2021 - annualreviews.org
In less than two decades, three deadly zoonotic coronaviruses, severe acute respiratory
syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS …
syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS …
[HTML][HTML] Coronaviruses exploit a host cysteine-aspartic protease for replication
Highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus
2 (refs.,)(SARS-CoV-2), Middle East respiratory syndrome coronavirus (MERS-CoV) and …
2 (refs.,)(SARS-CoV-2), Middle East respiratory syndrome coronavirus (MERS-CoV) and …
The ORF8 protein of SARS-CoV-2 induced endoplasmic reticulum stress and mediated immune evasion by antagonizing production of interferon beta
F Rashid, EE Dzakah, H Wang, S Tang - Virus research, 2021 - Elsevier
The open reading frame 8 (orf8) is an accessory protein of SARS-CoV-2. It has 121 amino
acids with two genotypes, orf8L and orf8S. In this study, we overexpressed the orf8L and …
acids with two genotypes, orf8L and orf8S. In this study, we overexpressed the orf8L and …
[HTML][HTML] Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing …
Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2
that the existing mRNA, adenoviral vector and inactivated vaccines fail to induce. Here, we …
that the existing mRNA, adenoviral vector and inactivated vaccines fail to induce. Here, we …
[HTML][HTML] Functions of coronavirus accessory proteins: overview of the state of the art
P Fang, L Fang, H Zhang, S Xia, S Xiao - Viruses, 2021 - mdpi.com
Coronavirus accessory proteins are a unique set of proteins whose genes are interspersed
among or within the genes encoding structural proteins. Different coronavirus genera, or …
among or within the genes encoding structural proteins. Different coronavirus genera, or …
[HTML][HTML] Suppression of cGAS-and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1
WY Lui, A Bharti, NHM Wong, S Jangra… - PLoS …, 2023 - journals.plos.org
Epstein-Barr virus (EBV) has developed effective strategies to evade host innate immune
responses. Here we reported on mitigation of type I interferon (IFN) production by EBV …
responses. Here we reported on mitigation of type I interferon (IFN) production by EBV …
Targeting papain-like protease for broad-spectrum coronavirus inhibition
The emergence of SARS-CoV-2 variants of concern and repeated outbreaks of coronavirus
epidemics in the past two decades emphasize the need for next-generation pan-coronaviral …
epidemics in the past two decades emphasize the need for next-generation pan-coronaviral …
[HTML][HTML] NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 …
I Tsukalov, I Sánchez-Cerrillo, O Rajas… - Nature …, 2024 - nature.com
Increased recruitment of transitional and non-classical monocytes in the lung during SARS-
CoV-2 infection is associated with COVID-19 severity. However, whether specific innate …
CoV-2 infection is associated with COVID-19 severity. However, whether specific innate …
Viral respiratory pathogens and lung injury
N Clementi, S Ghosh, M De Santis… - Clinical microbiology …, 2021 - Am Soc Microbiol
Several viruses target the human respiratory tract, causing different clinical manifestations
spanning from mild upper airway involvement to life-threatening acute respiratory distress …
spanning from mild upper airway involvement to life-threatening acute respiratory distress …