Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer's Disease

G Singh, S Kumar, SR Panda, P Kumar… - ACS Chemical …, 2024 - ACS Publications
Alzheimer's disease (AD) is the most prevalent cause of dementia and is characterized by
low levels of acetyl and butyrylcholine, increased oxidative stress, inflammation …

Rethinking common solvents in butyrylcholinesterase activity assays

UM Ghali, K Teralı, Ö Dalmızrak, N Özer - Inorganic Chemistry …, 2022 - Elsevier
Cholinesterases are a group of enzymes that prevent the message of the neurotransmitter
acetylcholine from being transmitted in an undesirable manner. The primary classes of this …

[HTML][HTML] Novel Organoruthenium (II) Complex C1 Selectively Inhibits Butyrylcholinesterase without Side Effects on Neuromuscular Transmission

T Trobec, MC Žužek, K Sepčić, J Kladnik… - International journal of …, 2023 - mdpi.com
Enzyme butyrylcholinesterase (BChE) shows increased activity in some brain regions after
progression of Alzheimer's disease and is therefore one of the therapeutic targets for …

[HTML][HTML] Kinetics and computational study of butyrylcholinesterase inhibition by methylrosmarinate: relevance to Alzheimer's disease treatment

SM Uzairu, Y Tijani, MA Gadaka, B Modu, M Watafua… - Heliyon, 2022 - cell.com
Butyrylcholinesterase (BChE) performs a significant function in Alzheimer's disease
progression. Experimental studies have shown that the function of BChE in the attenuation …

The Inhibition of Glutathione S-Transferases and Butyrylcholinesterase by Antidepressants: A Mini-Review on Enzyme-Drug Interactions

V Markus, Ö Dalmızrak, K Teralı… - Current Enzyme …, 2022 - ingentaconnect.com
Background: Compromises in the cellular enzymatic defense barrier can increase the
duration of exposure to electrophiles and the severity of toxicity they may incur. Objective: In …