Diabetes mellitus most commonly occurs after the neonatal period and results from complex
interactions between both environmental and incompletely penetrant genetic factors …

Abstract Potassium channels (K+-channels) selectively control the passive flow of potassium
ions across biological membranes and thereby also regulate membrane excitability. Genetic …

This chapter serves as an update and replaces the 2018 ISPAD consensus guideline on
definition, epidemiology, and classification of diabetes in children and adolescents. 1 It …

• Diagnostic criteria for all types of diabetes in children and adolescents are based on
laboratory measurement of plasma blood glucose levels (BGL) and the presence or …

Monogenic diabetes results from one or more defects in a single gene. The disease may be
inherited within families as a dominant, recessive or non-Mendelian trait or may present as a …

ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of
monogenic diabetes in children and adolescents - PMC Back to Top Skip to main content NIH …

Maria E Craiga, b, Craig Jefferiesc, Dana Dabelead, Naby Baldee, Anju Sethf and Kim C
Donaghuea aInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead …

Monogenic diabetes results from one or more defects in a single gene. The disease may be
inherited within families as a dominant, recessive, or non-Mendelian trait or may present as …

Individualization of therapy based on a person's specific type of diabetes is one key element
of a “precision medicine” approach to diabetes care. However, applying such an approach …

Activating mutations in one of the two subunits of the ATP-sensitive potassium (K ATP)
channel cause neonatal diabetes (ND). This may be either transient or permanent and, in …