Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

Obesity rates have escalated to the point of a global pandemic with varying prevalence
across ethnic groups. These differences are partially explained by lifestyle factors in addition …

One of the justifiable criticisms of human genetic studies is the underrepresentation of
participants from diverse populations. Lack of inclusion must be addressed at-scale to …

Positive selection in Europeans at the 2q21. 3 locus harboring the lactase gene has been
attributed to selection for the ability of adults to digest milk to survive famine in ancient times …

Between the 1930s and 1950s, scientists developed key principles of population genetics to
try and explain the aging process. Almost a century later, these aging theories, including …

Human obesity has a large genetic component, yet has many serious negative
consequences. How this state of affairs has evolved has generated wide debate. The thrifty …

Our understanding of human evolution has improved rapidly over recent decades, facilitated
by large‐scale cataloguing of genomic variability amongst both modern and archaic …

Food shortages represent a common challenge for most animal species. As a consequence,
many have evolved metabolic strategies encompassing extreme starvation-resistance …

Muller et al. have provided a strong critique of the Genome-Wide Association Studies
(GWAS) of body-mass index (BMI), arguing that the GWAS approach for the study of BMI is …

People completely lacking body fat (lipodystrophy/lipoatrophy) and those with severe
obesity both show profound metabolic and other health issues. Regulating levels of body fat …