It has been recognized that cancer is not merely a disease of tumor cells, but a disease of
imbalance, in which stromal cells and tumor microenvironment play crucial roles …

Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and
metastasis. This provided the rationale for clinical trials of MMP inhibitors, unfortunately with …

In recent years, the basement membrane (BM)—a specialized form of extracellular matrix
(ECM)—has been recognized as an important regulator of cell behaviour, rather than just a …

Entheses (insertion sites, osteotendinous junctions, osteoligamentous junctions) are sites of
stress concentration at the region where tendons and ligaments attach to bone …

Matrix metalloproteinases (MMPs) are a growing family of metalloendopeptidases that
cleave the protein components of the extracellular matrix and thereby play a central role in …

For more than two decades, the view that tumour-associated matrix metalloproteinases
(MMPs) were required for peritumour tissue degradation and metastasis dominated the drive …

Matrix metalloproteinases (MMPs) are a family of enzymes that proteolytically degrade
various components of the extracellular matrix (ECM). Angiogenesis is the process of …

The extracellular matrix (ECM) is a complex network of proteins, glycoproteins,
proteoglycans, and polysaccharides. Through multiple interactions with each other and the …

Extracellular proteolysis is an absolute requirement for new blood vessel formation
(angiogenesis). This review examines the role of the matrix metalloproteinase (MMP) and …

Background Angiogenesis is the process of neovascularization from pre-existing
vasculature and is involved in various physiological and pathological processes. Inhibitors …