With the explosion of genome-wide studies of regulated transcription, it has become clear
that traditional definitions of enhancers and promoters need to be revisited. These control …

▪ Abstract Extracellular stimuli elicit changes in gene expression in target cells by activating
intracellular protein kinase cascades that phosphorylate transcription factors within the …

Mammalian genomes are pervasively transcribed outside mapped protein-coding genes.
One class of extragenic transcription products is represented by long non-coding RNAs …

Histones are characterized by numerous posttranslational modifications that influence gene
transcription,. However, because of the lack of global distribution data in higher eukaryotic …

Gene expression is regulated by promoters, which initiate transcription, and enhancers,
which control their temporal and spatial activity. However, the discovery that mammalian …

Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to
control histone acetylation. As acetylation is a histone mark for active transcription, HATs …

The state of chromatin (the packaging of DNA in eukaryotes) has long been recognized to
have major effects on levels of gene expression, and numerous chromatin-altering …

The organization of eukaryotic chromatin has a major impact on all nuclear processes
involving DNA substrates. Gene expression is affected by the positioning of individual …

Proteins differentially interact with each other across cellular states and conditions, but an
efficient proteome-wide strategy to monitor them is lacking. We report the application of …

In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …