A successful pregnancy requires multiple adaptations in the mother's brain that serve to
optimise foetal growth and development, protect the foetus from adverse prenatal …

Stroke is a devastating neurovascular disease with limited therapeutic options. The
pathogenesis of stroke involves complex interrelated molecular mechanisms including …

Postnatal deficits in brain-derived neurotrophic factor (BDNF) are thought to contribute to
pathogenesis of Rett syndrome (RTT), a progressive neurodevelopmental disorder caused …

TRPV1 receptors feature prominently in nociception of spinal primary afferents but are also
expressed in unmyelinated cranial visceral primary afferents linked to homeostatic …

The hypothalamus–pituitary–adrenal (HPA) axis is the major neuroendocrine stress
response system. Corticotropin-releasing hormone (CRH) neurons in the parvocellular …

Peripheral chemoreceptor afferent information is sent to the nucleus tractus solitarii (nTS),
integrated, and relayed to other brain regions to alter cardiorespiratory function. The nTS …

Neurons in the brainstem dorsal vagal complex integrate neural and humoral signals to
coordinate autonomic output to viscera that regulate a variety of physiological functions, but …

Abstract The Food and Drug Administration has approved vagus-nerve stimulation (VNS) for
the treatment of patients with epilepsy, depression, and headache. By targeting diverse …

Leptin signaling within the nucleus of the solitary tract (NTS) contributes to the control of food
intake, and injections of leptin into the NTS reduce meal size and increase the efficacy of …

The afferent vagus transmits sensory information from the gastrointestinal (GI) tract and other
viscera to the brainstem via a glutamatergic synapse at the level of the nucleus of the solitary …