The incidence of hepatocellular carcinoma (HCC) is increasing in industrialized societies;
this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD) …

Liver disease is the spectrum of liver damage ranging from simple steatosis called as
nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC). Clinically …

Background & Aims Genetic factors associated with non-alcoholic fatty liver disease
(NAFLD) remain incompletely understood. To date, most genome-wide association studies …

Current therapeutic strategies for treating nonalcoholic steatohepatitis (NASH) have failed to
alleviate liver fibrosis, which is a devastating feature leading to hepatic dysfunction. Here …

Nearly 2.3 million individuals worldwide are coinfected with human immunodeficiency virus
(HIV) and hepatitis C virus (HCV). Odds of HCV infection are six times higher in people living …

Abstract The Cytochrome P450 (CYP) family 26 enzymes contribute to retinoic acid (RA)
metabolism and homeostasis in humans, mammals and other chordates. The three CYP26 …

Exosomes containing various biological cargoes have potential to be novel diagnostic
biomarkers for metabolic diseases. In this study, retinol-binding protein 4 (RBP4) was found …

Background & Aims Systemic retinol (vitamin A) homeostasis is controlled by the liver,
involving close collaboration between hepatocytes and hepatic stellate cells (HSCs) …

Conversion of dietary vitamin A (VA) into retinoic acid (RA) is essential for many biological
processes and thus far studied largely in mammalian cells. Using targeted metabolomics …

Several differential panels of metabolites have been associated with the presence of
metabolic syndrome and its related conditions, namely non-alcoholic fatty liver disease …