Currently, enhancement of cholinergic neurotransmission via cholinesterase inhibitors
represents the main available approach to treat cognitive and behavioural symptoms of the …

Alzheimer's disease, a major and increasing global health challenge, is an irreversible,
progressive form of dementia, associated with an ongoing decline of brain functioning. The …

Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

Since the first discovery of antipsychotics in the 1950s, targeting dopaminergic drugs has
manifested to well manage the positive symptoms of schizophrenia with limited efficacy for …

Depression and cognitive disorders are diseases with complex and not-fully understood
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …

Emerging research has re-emphasized the role of the cortical cholinergic system in the
symptomology and progression of Alzheimer's disease (AD). Basal forebrain (BF) …

Alzheimer's disease (AD) is a multifactorial neurodegenerative pathology characterized by a
progressive decline of cognitive functions. Alteration of various signaling cascades affecting …

ABSTRACT Introduction: The sigma-1 receptor (S1R) is attracting much attention for disease-
modifying therapies in neurodegenerative diseases. It is a conserved protein, present in …

The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure.
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding …

A large body of evidence indicates that sigma-1 receptors (Sig-1R) are important drug
targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous …