Background Some psychotropic medications have been associated with prolongation of the
QT interval and QT prolongation, especially in those with medical illness, and are linked to …

We comprehensively reviewed published literature to determine whether it supported the
link between corrected QT (QTc) interval prolongation and torsade de pointes (TdP) for the …

The ventricular arrhythmia Torsades de Pointes (TdP) is a common form of drug‐induced
cardiotoxicity, but prediction of this arrhythmia remains an unresolved issue in drug …

Torsade de Pointes (TdP), a rare but lethal ventricular arrhythmia, is a toxic side effect of
many drugs. To assess TdP risk, safety regulatory guidelines require quantification of hERG …

Sudden cardiac death is a major public health challenge, which can be caused by genetic or
acquired structural or electrophysiological abnormalities. These abnormalities include …

Objective Several psychiatric medications have the potential to prolong the QTc interval and
subsequently increase the risk for ventricular arrhythmias such as torsades de pointes (TdP) …

Prolongation of the QT interval on an ECG is a surrogate marker for predicting the
proarrhythmic potential of a drug under development. The aim of this study was to evaluate …

Quetiapine, an atypical antipsychotic used in the intensive care unit (ICU) to manage
delirium, has a possible adverse effect of corrected QT (QTc) interval prolongation. The …

Background: Acetylcholinesterase inhibitors (AChEis) including donepezil, galantamine and
rivastigmine are used to treat Alzheimer's disease (AD). This study aimed to evaluate …

Background Torsade de pointes is a potentially lethal polymorphic ventricular
tachyarrhythmia that can occur in the setting of long QT syndrome (LQTS). LQTS is multi-hit …