Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …

Hybrid molecules have the potential to enhance the efficacy against both drug-sensitive and
drug-resistant organisms, and Ferroquine, a ferrocene hybrid, has demonstrated great …

Introduction: Chalcones are attractive to synthetic chemists because they are easy to
prepare, have a large number of replaceable hydrogens, thereby having significant …

Malaria, one of the most striking, re‐emerging infectious diseases caused by the genus
Plasmodium, places a huge burden on global healthcare systems. A major challenge in the …

Malaria is a tropical disease, leading to around half a million deaths annually. Antimalarials
such as quinolines are crucial to fight against malaria, but malaria control is extremely …

Quinoline-isoniazid-phthalimide triads have been synthesised to assess their antiplasmodial
efficacy and cytotoxicity against chloroquine-resistant W2 strain of P. falciparum and Vero …

Background Malaria is a complex issue due to the availability of few therapies and chemical
families against Plasmodium and mosquitoes. There is increasing resistance to various …

ATP-binding cassette subfamily G and tubulin pharmacological mechanisms decrease the
effectiveness of anticancer drugs by modulating drug absorption and by creating tubulin …

Aim: WHO Malaria report 2017 estimated 216 million cases of malaria and 445,000 deaths
worldwide, with 91% of deaths affecting the African region. Results/methodology: Microwave …

Apicomplexian parasite of the genus Plasmodium is the causative agent of malaria, one of
the most devastating, furious and common infectious disease throughout the world …