The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …

Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins
(PFPs) that function as executioners of specific cell death pathways: apoptosis regulator …

Exposure of cells to high voltage electric pulses increases transiently membrane
permeability through membrane electroporation. Electroporation can be reversible and is …

Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell
death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM) …

Abstract During apoptosis, the BCL‐2‐family protein tBID promotes mitochondrial
permeabilization by activating BAX and BAK and by blocking anti‐apoptotic BCL‐2 …

Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis
that activates the caspase cascade and irreversibly causes the majority of cells to die. The …

The conserved lipase-like protein EDS1 transduces signals from pathogen-activated
intracellular nucleotide-binding leucine-rich repeat (NLR) receptors to transcriptional …

The survival of viruses depends on their ability to resist host defenses and, of all animal virus
families, the poxviruses have the most antidefense genes. Orthopoxviruses (ORPV), a genus …