Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
PE Czabotar, AJ Garcia-Saez - Nature reviews Molecular cell biology, 2023 - nature.com
The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …
either promoters or inhibitors of cell death. The functional interplay and balance between the …
The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
S Qian, Z Wei, W Yang, J Huang, Y Yang… - Frontiers in …, 2022 - frontiersin.org
Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways
P Vandenabeele, G Bultynck… - Nature Reviews Molecular …, 2023 - nature.com
Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins
(PFPs) that function as executioners of specific cell death pathways: apoptosis regulator …
(PFPs) that function as executioners of specific cell death pathways: apoptosis regulator …
[HTML][HTML] Cell death due to electroporation–a review
TB Napotnik, T Polajžer, D Miklavčič - Bioelectrochemistry, 2021 - Elsevier
Exposure of cells to high voltage electric pulses increases transiently membrane
permeability through membrane electroporation. Electroporation can be reversible and is …
permeability through membrane electroporation. Electroporation can be reversible and is …
Apoptosis, pyroptosis, and necroptosis—Oh my! The many ways a cell can die
N Ketelut-Carneiro, KA Fitzgerald - Journal of molecular biology, 2022 - Elsevier
Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …
Physiological and pharmacological modulation of BAX
AZ Spitz, E Gavathiotis - Trends in pharmacological sciences, 2022 - cell.com
Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell
death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM) …
death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM) …
BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis
H Flores‐Romero, L Hohorst, M John, MC Albert… - The EMBO …, 2022 - embopress.org
Abstract During apoptosis, the BCL‐2‐family protein tBID promotes mitochondrial
permeabilization by activating BAX and BAK and by blocking anti‐apoptotic BCL‐2 …
permeabilization by activating BAX and BAK and by blocking anti‐apoptotic BCL‐2 …
[HTML][HTML] Apoptosis regulation at the mitochondria membrane level
Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis
that activates the caspase cascade and irreversibly causes the majority of cells to die. The …
that activates the caspase cascade and irreversibly causes the majority of cells to die. The …
[HTML][HTML] EDS1 signalling: At the nexus of intracellular and surface receptor immunity
JA Dongus, JE Parker - Current opinion in plant biology, 2021 - Elsevier
The conserved lipase-like protein EDS1 transduces signals from pathogen-activated
intracellular nucleotide-binding leucine-rich repeat (NLR) receptors to transcriptional …
intracellular nucleotide-binding leucine-rich repeat (NLR) receptors to transcriptional …
Ancient gene capture and recent gene loss shape the evolution of orthopoxvirus-host interaction genes
The survival of viruses depends on their ability to resist host defenses and, of all animal virus
families, the poxviruses have the most antidefense genes. Orthopoxviruses (ORPV), a genus …
families, the poxviruses have the most antidefense genes. Orthopoxviruses (ORPV), a genus …