Dietary polyphenols represent a wide variety of compounds that occur in fruits, vegetables,
wine, tea, extra virgin olive oil, chocolate and other cocoa products. They are mostly …

In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease
in cellular drug accumulation which is attributed to the overexpression of certain ATP …

Over 1 million new cases of all types of cancer are diagnosed each year in the United States
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …

In this review we give an overview of the physiological functions of a group of ATP binding
cassette (ABC) transporter proteins, which were discovered, and still referred to, as …

This review critically surveys the literature published mainly within this millennium on the
new and emerging applications of silybin (pure, chemically defined substance) and …

Human ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily and
is known to contribute to multidrug resistance (MDR) in cancer chemotherapy. Among ABC …

Resveratrol is a polyphenol that among other sources occurs in grapes and for this reason,
red wines also contain considerable amounts of this compound. Resveratrol is thought to be …

The blood-brain barrier (BBB) and blood-cerebrospinal fluid (BCSF) barriers are critical
determinants of CNS homeostasis. Additionally, the BBB and BCSF barriers are formidable …

Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical
treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be …

The polyphenol resveratrol is an anticancer nutrient that was shown to inhibit cancer
initiation and promotion [Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW …