In cancer patients, dendritic cells (DCs) in tumor-draining lymph nodes can present antigens
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …

The immune system has crucial roles in cancer development and treatment. Whereas
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …

Almost a quarter century has passed since discovery of receptor activator of NF-κB ligand
(RANKL). This discovery had a major impact on identification of mechanisms regulating …

Background In postmenopausal women with hormone receptor-positive, early-stage breast
cancer, treatment with adjuvant aromatase inhibitors is the standard of care, but it increases …

Since the receptor activator of nuclear factor-kappa B ligand (RANKL), its cognate receptor
activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) …

IL-1β is a proinflammatory mediator with roles in innate and adaptive immunity. Here we
show that IL-1β contributes to autoimmune arthritis by inducing osteoclastogenic capacity in …

The immune system has evolved complex effector mechanisms to protect the host against a
diversity of pathogenic organisms and regulatory adaptations that can curtail pathological …

A substantial amount patients with cancer will develop bone metastases, with 70% of
metastatic prostate and breast cancer patients harboring bone metastasis. Despite …

Melanoma is an immunogenic tumor whose relationship with immune cells resident in the
microenvironment significantly influences cancer cell proliferation, progression, and …

Chronic inflammatory processes in the oral mucosa and periodontitis are common disorders
caused by microflora and microbial biofilms. These factors activate both the innate and …