HES and HERP families: multiple effectors of the Notch signaling pathway
T Iso, L Kedes, Y Hamamori - Journal of cellular physiology, 2003 - Wiley Online Library
Notch signaling dictates cell fate and critically influences cell proliferation, differentiation,
and apoptosis in metazoans. Multiple factors at each step—ligands, receptors, signal …
and apoptosis in metazoans. Multiple factors at each step—ligands, receptors, signal …
Transcription factor Bhlhe40 in immunity and autoimmunity
ME Cook, NN Jarjour, CC Lin, BT Edelson - Trends in immunology, 2020 - cell.com
The basic helix-loop-helix transcription factor (TF) Bhlhe40 is emerging as a key regulator of
immunity during infection, autoimmunity, and inflammatory conditions. We describe the roles …
immunity during infection, autoimmunity, and inflammatory conditions. We describe the roles …
The transcription factor Bhlhe40 programs mitochondrial regulation of resident CD8+ T cell fitness and functionality
Tissue-resident memory CD8+ T (Trm) cells share core residency gene programs with tumor-
infiltrating lymphocytes (TILs). However, the transcriptional, metabolic, and epigenetic …
infiltrating lymphocytes (TILs). However, the transcriptional, metabolic, and epigenetic …
Regulatory T cell development in the absence of functional Foxp3
W Lin, D Haribhai, LM Relland, N Truong… - Nature …, 2007 - nature.com
Although the development of regulatory T cells (Treg cells) in the thymus is defined by
expression of the lineage marker Foxp3, the precise function of Foxp3 in Treg cell lineage …
expression of the lineage marker Foxp3, the precise function of Foxp3 in Treg cell lineage …
Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation
CC Lin, TR Bradstreet, EA Schwarzkopf, J Sim… - Nature …, 2014 - nature.com
TH1 and TH17 cells mediate neuroinflammation in experimental autoimmune
encephalomyelitis (EAE), a mouse model of multiple sclerosis. Pathogenic TH cells in EAE …
encephalomyelitis (EAE), a mouse model of multiple sclerosis. Pathogenic TH cells in EAE …
Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self‐renewal and identity
R Rauschmeier, C Gustafsson, A Reinhardt… - The EMBO …, 2019 - embopress.org
Tissues in multicellular organisms are populated by resident macrophages, which perform
both generic and tissue‐specific functions. The latter are induced by signals from the …
both generic and tissue‐specific functions. The latter are induced by signals from the …
Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection
The cytokine IL-10 antagonizes pathways that control Mycobacterium tuberculosis (Mtb)
infection. Nevertheless, the impact of IL-10 during Mtb infection has been difficult to decipher …
infection. Nevertheless, the impact of IL-10 during Mtb infection has been difficult to decipher …
A LAT mutation that inhibits T cell development yet induces lymphoproliferation
CL Sommers, CS Park, J Lee, C Feng, CL Fuller… - Science, 2002 - science.org
Mice homozygous for a single tyrosine mutation in LAT (linker for activation of T cells)
exhibited an early block in T cell maturation but later developed a polyclonal …
exhibited an early block in T cell maturation but later developed a polyclonal …
The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination
Type 1 T helper (Th1) cells play a critical role in host defense against intracellular pathogens
and in autoimmune diseases by producing a key inflammatory cytokine interferon (IFN)–γ; …
and in autoimmune diseases by producing a key inflammatory cytokine interferon (IFN)–γ; …
Induction of T helper type 2 immunity by a point mutation in the LAT adaptor
The transmembrane protein LAT (linker for activation of T cells) couples the T cell receptor
(TCR) to downstream signaling effectors. Mice homozygous for a mutation of a single LAT …
(TCR) to downstream signaling effectors. Mice homozygous for a mutation of a single LAT …