Abstract The Na+ and Ca 2+-permeable melastatin related transient receptor potential
(TRPM2) cation channels can be gated either by ADP-ribose (ADPR) in concert with Ca 2+ …

The precise mechanistic sequence producing the beneficial effects on health and lifespan
seen with interventions as diverse as caloric restriction, intermittent fasting, exercise, and …

Background Studies have shown a relationship between prefrontal cortex (PFC) activation
asymmetry and psychological responses to exercise, so that a higher rest activation in left …

The physiological significance of cardiac mitochondrial uncoupling protein 2 (UCP2)-
mediated uncoupling respiration in exercise is unknown. In the current study, mitochondrial …

The present study investigated mitochondrial adaptations and oxidative damage after 4 and
8 weeks of running training in skeletal muscle of mice. Twenty-one male mice (CF1, 30–35 …

Witch hazel (Hammamelis virginiana) bark is a rich source of both condensed and
hydrolizable oligomeric tannins. From a polyphenolic extract soluble in both ethyl acetate …

Melastatin-like transient receptor potential 2 (TRPM2) channel is a redox sensitive Ca2+-
permeable cation channel that can be gated by H2O2 binding to the channel's enzymatic …

Oxidative stress occurs during maximal exercise, perhaps as a result of increased
consumption of oxygen. Vitamins C and E can overcome the effects of antioxidants in …

Oxidative stress has been linked strongly to cell death and cardiac remodeling processes,
all hallmarks of heart failure. Mice deficient for desmin (des-/-), the major muscle specific …

Hamamelis virginiana (witch hazel) bark is a rich source of condensed and hydrolyzable
tannins reported to exert a protective action against colon cancer. The present study …