Bisphosphonates are considered the most effective drugs for controlling adult and pediatric
osteolytic diseases. Although they have been used successfully for many years, several side …

Tooth eruption is a pivotal milestone for children's growth and development. This process
involves with the formation of the tooth root, the periodontal ligament (PDL) and the alveolar …

Periodontitis is based on a complex inflammatory over-response combined with possible
genetic predisposition factors. The RANKL/RANK/OPG signaling pathway is implicated in …

It has been difficult to examine the role of TGF-ß in post-natal tooth development due to
perinatal lethality in many of the signaling deficient mouse models. To address the role of …

Background: The great variability of periodontal and systemic responses to experimental
periodontitis reflects the inherent pathogenic complexity of mice models and could limit the …

We explored the relationship between growth in tooth root length and the modern human
extended period of childhood. Tooth roots provide support to counter chewing forces and so …

Cleidocranial dysplasia is an autosomal dominant skeletal disorder resulting from RUNX2
mutations. The influence of RUNX2 mutations on osteoclastogenesis and bone resorption …

Periodontal bone tissue defects and bone shortages are the most familiar and troublesome
clinical problems in the oral cavity. Stem cell-derived extracellular vesicles (SC-EVs) have …

A tenet of mammalian, including primate dental evolution, is the Inhibitory Cascade Model,
where first molar (M1) size predicts in a linear cline the size and onset time of the second …

RANK and its ligand RANKL play important roles in the development and regulation of the
immune system. We show that mice transgenic for Rank in hair follicles display massive …