Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
Autophagy in healthy aging and disease
Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …
[HTML][HTML] Autophagy in inflammation, infection, and immunometabolism
V Deretic - Immunity, 2021 - cell.com
Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …
Vitamin D, infections and immunity
A Ismailova, JH White - Reviews in Endocrine and Metabolic Disorders, 2022 - Springer
Vitamin D, best known for its role in skeletal health, has emerged as a key regulator of innate
immune responses to microbial threat. In immune cells such as macrophages, expression of …
immune responses to microbial threat. In immune cells such as macrophages, expression of …
Interplay between NLRP3 inflammasome and autophagy
M Biasizzo, N Kopitar-Jerala - Frontiers in Immunology, 2020 - frontiersin.org
The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …
Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease
Cigarette smoking is the leading cause of preventable death worldwide. It causes chronic
lung disease and predisposes individuals to acute lung injury and pulmonary infection …
lung disease and predisposes individuals to acute lung injury and pulmonary infection …
Alteration of gut microbiota in inflammatory bowel disease (IBD): cause or consequence? IBD treatment targeting the gut microbiome
Inflammatory bowel disease (IBD) is a chronic complex inflammatory gut pathological
condition, examples of which include Crohn's disease (CD) and ulcerative colitis (UC) …
condition, examples of which include Crohn's disease (CD) and ulcerative colitis (UC) …
Constitutive immune mechanisms: mediators of host defence and immune regulation
The immune system enables organisms to combat infections and to eliminate endogenous
challenges. Immune responses can be evoked through diverse inducible pathways …
challenges. Immune responses can be evoked through diverse inducible pathways …
Mechanism and medical implications of mammalian autophagy
Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …
cellular stress, which prevents cell damage and promotes survival in the event of energy or …
Life, death and autophagy
J Doherty, EH Baehrecke - Nature cell biology, 2018 - nature.com
Autophagy influences cell survival through maintenance of cell bioenergetics and clearance
of protein aggregates and damaged organelles. Several lines of evidence indicate that …
of protein aggregates and damaged organelles. Several lines of evidence indicate that …