Large-scale neural recordings call for new insights to link brain and behavior
Neuroscientists today can measure activity from more neurons than ever before, and are
facing the challenge of connecting these brain-wide neural recordings to computation and …
facing the challenge of connecting these brain-wide neural recordings to computation and …
A guide to light-sheet fluorescence microscopy for multiscale imaging
RM Power, J Huisken - Nature methods, 2017 - nature.com
The impact of light-sheet fluorescence microscopy (LSFM) is visible in fields as diverse as
developmental and cell biology, anatomical science, biophysics and neuroscience …
developmental and cell biology, anatomical science, biophysics and neuroscience …
[HTML][HTML] Real-time denoising enables high-sensitivity fluorescence time-lapse imaging beyond the shot-noise limit
A fundamental challenge in fluorescence microscopy is the photon shot noise arising from
the inevitable stochasticity of photon detection. Noise increases measurement uncertainty …
the inevitable stochasticity of photon detection. Noise increases measurement uncertainty …
[HTML][HTML] NeuroPAL: a multicolor atlas for whole-brain neuronal identification in C. elegans
Comprehensively resolving neuronal identities in whole-brain images is a major challenge.
We achieve this in C. elegans by engineering a multicolor transgene called NeuroPAL (a …
We achieve this in C. elegans by engineering a multicolor transgene called NeuroPAL (a …
A survey on applications of deep learning in microscopy image analysis
Z Liu, L Jin, J Chen, Q Fang, S Ablameyko, Z Yin… - Computers in biology …, 2021 - Elsevier
Advanced microscopy enables us to acquire quantities of time-lapse images to visualize the
dynamic characteristics of tissues, cells or molecules. Microscopy images typically vary in …
dynamic characteristics of tissues, cells or molecules. Microscopy images typically vary in …
From the neuron doctrine to neural networks
R Yuste - Nature reviews neuroscience, 2015 - nature.com
For over a century, the neuron doctrine—which states that the neuron is the structural and
functional unit of the nervous system—has provided a conceptual foundation for …
functional unit of the nervous system—has provided a conceptual foundation for …
[HTML][HTML] Global brain dynamics embed the motor command sequence of Caenorhabditis elegans
While isolated motor actions can be correlated with activities of neuronal networks, an
unresolved problem is how the brain assembles these activities into organized behaviors …
unresolved problem is how the brain assembles these activities into organized behaviors …
Swept confocally-aligned planar excitation (SCAPE) microscopy for high-speed volumetric imaging of behaving organisms
MB Bouchard, V Voleti, CS Mendes, C Lacefield… - Nature …, 2015 - nature.com
We report a three-dimensional microscopy technique—swept, confocally-aligned planar
excitation (SCAPE) microscopy—that allows volumetric imaging of living samples at …
excitation (SCAPE) microscopy—that allows volumetric imaging of living samples at …
Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy
High-speed, large-scale three-dimensional (3D) imaging of neuronal activity poses a major
challenge in neuroscience. Here we demonstrate simultaneous functional imaging of …
challenge in neuroscience. Here we demonstrate simultaneous functional imaging of …