Post-stroke depression (PSD) is one of common and serious sequelae of stroke.
Approximately, one in three stroke survivors suffered from depression after stroke. It heavily …

Childhood maltreatment is a major risk factor for chronic and severe mental and physical
health problems across the lifespan. Increasing evidence supports the hypothesis that …

Mounting evidence suggests that gut microbiota can play an important role in
pathophysiology of depression, but its specific molecular mechanisms are still unclear. This …

DNA methylation (DNAm)–an epigenetic process that regulates gene expression–may
represent a mechanism for the biological embedding of early traumatic experiences …

Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …

Mental disorders are highly complex and multifactorial in origin, comprising an elaborate
interplay of genetic and environmental factors. Epigenetic mechanisms such as DNA …

Medial temporal lobe structures have long been implicated in the pathogenesis of major
depressive disorder. Although findings of smaller hippocampal and amygdalar volumes are …

Stress is an adaptive response to environment aversive stimuli and a common life
experience of one's daily life. Chronic or excessive stress especially that happened in early …

Major depressive disorder (MDD) is a serious psychiatric disorder that associated with high
rate of disability and increasing suicide rate, and the pathogenesis is still unclear. Many …

The impacts of glucocorticoids (GCs) are mainly mediated by a nuclear receptor (GR)
existing in almost every tissue. The GR regulates a wide range of physiological functions …