Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important
thiol reducing agent involved in the modulation of redox processes. It has also been …

Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …

Drug-induced acute liver failure carries a high morbidity and mortality rate. Acetaminophen
overdose is the number one cause of acute liver failure and remains a major problem in …

Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Inflammation In the absence of pathogens occurs in all tissues in response to a wide range
of stimuli that cause tissue stress and injury. Such sterile inflammation (SI) is a key process …

Hepatic ischemia/reperfusion (I/R) injury is a major complication of liver surgery, including
liver resection, liver transplantation, and trauma surgery. Much has been learned about the …

Uric acid is the final product of purine metabolism in humans. The final two reactions of its
production catalyzing the conversion of hypoxanthine to xanthine and the latter to uric acid …

Kupffer cells (KC) constitute 80–90% of the tissue macrophages present in the body. They
reside within the lumen of the liver sinusoids, and are therefore constantly exposed to gut …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Liver cell death induced by stresses such as ischemia‐reperfusion, cholestasis and drug
toxicity can trigger a sterile inflammatory response with activation of innate immune cells …