The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

The global obesity epidemic is a major contributor to chronic disease and disability in the
world today. Since the discovery of leptin in 1994, a multitude of studies have characterized …

Sarcopenia, an age-associated decline in skeletal muscle mass coupled with functional
deterioration, may be exacerbated by obesity leading to higher disability, frailty, morbidity …

Obesity increases the risk for metabolic, cardiovascular, chronic inflammatory, and several
malignant diseases and, therefore, may contribute to shortened lifespan. Adipokines are …

Metabolic syndrome is a global public health problem and predisposes individuals to
obesity, diabetes and cardiovascular disease. Although the underlying mechanisms remain …

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

The coordination of nutrient sensing, delivery, uptake and utilization is essential for
maintaining cellular, tissue and whole-body homeostasis. Such synchronization can be …

The worldwide obesity epidemic has become a major health concern, because it contributes
to higher mortality due to an increased risk for noncommunicable diseases including …

This year marks the 20th anniversary of the discovery of leptin, which has tremendously
stimulated translational obesity research. The discovery of leptin has led to realizations that …

Obesity significantly increases the risk of developing type 2 diabetes, hypertension, coronary
heart disease, stroke, fatty liver disease, dementia, obstructive sleep apnea and several …