Alzheimer's disease (AD) is caused by synaptic and neuronal loss in the brain. One of the
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …

Alzheimer's disease (AD) is the primary cause of age-related dementia. Effective strategies
to prevent and treat AD remain elusive despite major efforts to understand its basic biology …

Background Increased levels of the pathogenic amyloid β-peptide (Aβ), released from its
precursor by the transmembrane protease γ-secretase, are found in Alzheimer disease (AD) …

Mitochondria are physically and biochemically in contact with other organelles including the
endoplasmic reticulum (ER). Such contacts are formed between mitochondria‐associated …

γ-Secretase is an aspartyl intramembranal protease composed of presenilin, Nicastrin,
Aph1, and Pen2 with 19 transmembrane domains. γ-Secretase cleaves the amyloid …

Oligodendrocytes extend elaborate microtubule arbors that contact up to 50 axon segments
per cell, then spiral around myelin sheaths, penetrating from outer to inner layers. However …

Abstract γ-Secretase cleavage is essential for many biological processes and its
dysregulation is linked to disease, including cancer and Alzheimer's disease. Therefore …

Classically, animal cells nucleate or form new microtubules off the perinuclear centrosome.
In recent years, the Golgi outpost has emerged as a satellite organelle that can function as …

Transcription, translation, and turnover of transcripts and proteins are essential for cellular
function. The contribution of those factors to protein levels is under debate, as transcript …

γ-Secretase is a four subunit, 19-pass transmembrane enzyme that cleaves amyloid
precursor protein (APP), catalyzing the formation of amyloid beta (Aβ) peptides that form …