Potential impact of the multi-target drug approach in the treatment of some complex diseases

XH Makhoba, C Viegas Jr, RA Mosa… - Drug design …, 2020 - Taylor & Francis
It is essential to acknowledge the efforts made thus far to manage or eliminate various
disease burden faced by humankind. However, the rising global trends of the so-called …

The Effect of Supplementing Mushroom Growing Substrates on the Bioactive Compounds, Antimicrobial Activity, and Antioxidant Activity of Pleurotus ostreatus

SS Mkhize, MB Cedric Simelane… - Biochemistry …, 2022 - Wiley Online Library
Pleurotus ostreatus mushroom contains important bioactive compounds and has several
biological activities; however, mushroom growing substrates have major influence on …

[HTML][HTML] Toxicity and phytochemical properties of southern African medicinal plants used traditionally to treat pain and inflammatory ailments

GP Khumalo, BE Van Wyk, Y Feng, IE Cock - South African Journal of …, 2023 - Elsevier
The harmful side effects associated with conventional anti-inflammatory pharmaceuticals
has focussed attention on medicinal plants as alternative therapeutics. However, the use of …

[HTML][HTML] Iso-mukaadial acetate and ursolic acid acetate inhibit the chaperone activity of Plasmodium falciparum heat shock protein 70-1

N Salomane, OJ Pooe, MBC Simelane - Cell Stress and Chaperones, 2021 - Elsevier
Plasmodium falciparum is the most lethal malaria parasite. The present study investigates
the interaction capabilities of select plant derivatives, iso-mukaadial acetate (IMA) and …

Bioprospecting the Biological Effects of Cultivating Pleurotus ostreatus Mushrooms from Selected Agro‐Wastes and Maize Flour Supplements

SS Mkhize, MBC Simelane… - Journal of Food …, 2023 - Wiley Online Library
Pleurotus mushrooms are valuable food supplements with health and environmental
restorative potential. In this paper, we sought to evaluate the biological activities and profile …

[HTML][HTML] Bioprospecting the liver protective activity of betulinic acid isolated from the stem bark of Ziziphus mucronata Willd. subsp. mucronata

G Ayeni, MBC Simelane, S Yakobi, S Makumire… - Scientific African, 2024 - Elsevier
Abstract In traditional African medicine, Ziziphus mucronata Willd. subsp. mucronata is used
in the treatment of chronic cough, boils, toothache, rheumatism, diabetes, hypertension …

Evaluation of 100 most cited research articles on African medicinal plants

K Okaiyeto, OO Oguntibeju - Plant Science Today, 2021 - horizonepublishing.com
The mission for drug discovery and progress has prompt researchers to scientifically
validate the therapeutic uses of medicinal plants available worldwide, of which, African …

Mushroom‐derived products as an alternative antimalarial therapeutics: A Review

SS Mkhize, KE Machaba… - Drug Development for …, 2022 - Wiley Online Library
Edible and medicinal mushrooms have been highlighted to contain potent antiparasitic
activity, due to their vast phytochemical content. Mushroom can be defined as a macro …

Evaluating the antioxidant and heavy metal content of Pleurotus ostreatus mushrooms cultivated using sugar cane agro-waste

SS Mkhize, MBC Simelane, NL Gasa… - Pharmacognosy …, 2021 - phcogj.com
Background: Pleurotus ostreatus, is one of the most cultivated mushrooms with great
economic and medicinal value that can be easily grown on various bio-waste substrates …

[PDF][PDF] Chemical Elucidation, Microbial Growth and Free Radical Inhibitory Effects of Dennettia tripetala Fruit: In vitro and In vivo Model Experiments.

A Gideon, LA Rotimi, Y Abdulrazaq… - Tropical Journal of …, 2023 - researchgate.net
Natural products are being exploited in the treatment of diverse ailments stemming from
microbial and free radical incursion in the African native societies. The current study was …