[HTML][HTML] Seventy years of Chlamydia vaccine research–limitations of the past and directions for the future

S Phillips, BL Quigley, P Timms - Frontiers in microbiology, 2019 - frontiersin.org
Chlamydia is a major bacterial pathogen that infects humans, as well as a wide range of
animals, including marsupials, birds, cats, pigs, cattle, and sheep. Antibiotics are the only …

Update on Chlamydia trachomatis vaccinology

LM de la Maza, G Zhong… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
Attempts to produce a vaccine to protect against Chlamydia trachomatis-induced trachoma
were initiated more than 100 years ago and continued for several decades. Using whole …

Vaccination against Chlamydia Genital Infection Utilizing the Murine C. muridarum Model

CM Farris, RP Morrison - Infection and immunity, 2011 - Am Soc Microbiol
Chlamydia trachomatis genital infection is a worldwide public health problem, and
considerable effort has been expended on developing an efficacious vaccine. The murine …

Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?

LM de la Maza, TL Darville, S Pal - Expert review of vaccines, 2021 - Taylor & Francis
Introduction Chlamydia trachomatis is the most common sexually transmitted bacterial
pathogen in the world. Antibiotic treatment does not prevent against reinfection and a …

CD4+ T Cells and Antibody Are Required for Optimal Major Outer Membrane Protein Vaccine-Induced Immunity to Chlamydia muridarum Genital Infection

CM Farris, SG Morrison, RP Morrison - Infection and immunity, 2010 - Am Soc Microbiol
Despite effective antimicrobial chemotherapy, control of Chlamydia trachomatis urogenital
infection will likely require a vaccine. We have assessed the protective effect of an outer …

Chlamydia trachomatis, a Hidden Epidemic: Effects on Female Reproduction and Options for Treatment

AJ Carey, KW Beagley - American journal of reproductive …, 2010 - Wiley Online Library
Citation Carey AJ, Beagley KW. Chlamydia trachomatis, a hidden epidemic: effects on the
female reproduction and options for treatment. Am J Reprod Immunol 2010 The number of …

Mice deficient in MyD88 develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infection

L Chen, L Lei, X Chang, Z Li, C Lu, X Zhang… - The Journal of …, 2010 - journals.aai.org
MyD88, a key adaptor molecule required for many innate immunity receptor-activated
signaling pathways, was evaluated in a Chlamydia muridarum urogenital tract infection …

Chlamydia vaccine candidates and tools for chlamydial antigen discovery

DD Rockey, J Wang, L Lei, G Zhong - Expert review of vaccines, 2009 - Taylor & Francis
The failure of the inactivated Chlamydia-based vaccine trials in the 1960s has led
researchers studying Chlamydia to take cautious and rational approaches to develop safe …

The mouse model of Chlamydia genital tract infection: a review of infection, disease, immunity and vaccine development

CP O'Meara, DW Andrew… - Current molecular …, 2014 - ingentaconnect.com
Chlamydia trachomatis is the most common sexually transmitted bacterial infection
worldwide. The impact of this pathogen on human reproduction has intensified research …

Vaccination with the defined chlamydial secreted protein CPAF induces robust protection against female infertility following repeated genital chlamydial challenge

AK Murthy, W Li, MN Guentzel, G Zhong… - Vaccine, 2011 - Elsevier
We previously have shown the efficacy of recombinant (r) chlamydial protease-like activity
factor (CPAF) vaccination against hydrosalpinx development following primary genital …