Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as
constitutive and alternative splicing regulators. As splicing is linked to transcriptional and …

Point mutations in the coding regions of genes are commonly assumed to exert their effects
by altering single amino acids in the encoded proteins. However, there is increasing …

Serine/arginine-rich splicing factor 3 (SRSF3) regulates mRNA alternative splicing of more
than 90% of protein-coding genes, providing an essential source for biological versatility …

Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by
specific adaptor proteins. How and why cells use numerous different export adaptors is …

The SR protein family comprises a number of phylogenetically conserved and structurally
related proteins with a characteristic domain rich in arginine and serine residues, known as …

Abstract mRNA is packaged into ribonucleoprotein particles called mRNPs. A multitude of
RNA-binding proteins as well as a host of associated proteins participate in the fate of …

The messenger RNA processing reactions of capping, splicing, and polyadenylation occur
cotranscriptionally. They not only influence one another's efficiency and specificity, but are …

Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …

Alternative mRNA processing is a critical mechanism for proteome expansion and gene
regulation in higher eukaryotes. The SR family proteins play important roles in splicing …

ABSTRACT Messenger RNA (mRNA) 3′ end formation is a nuclear process through which
all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a …