Ischaemic stroke

BCV Campbell, DA De Silva, MR Macleod… - Nature reviews Disease …, 2019 - nature.com
Stroke is the second highest cause of death globally and a leading cause of disability, with
an increasing incidence in developing countries. Ischaemic stroke caused by arterial …

Extending thrombolysis to 4· 5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data

BCV Campbell, H Ma, PA Ringleb, MW Parsons… - The Lancet, 2019 - thelancet.com
Background Stroke thrombolysis with alteplase is currently recommended 0–4· 5 h after
stroke onset. We aimed to determine whether perfusion imaging can identify patients with …

Thrombolysis guided by perfusion imaging up to 9 hours after onset of stroke

H Ma, BCV Campbell, MW Parsons… - … England Journal of …, 2019 - Mass Medical Soc
Background The time to initiate intravenous thrombolysis for acute ischemic stroke is
generally limited to within 4.5 hours after the onset of symptoms. Some trials have suggested …

[HTML][HTML] Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis

JM Wardlaw, V Murray, E Berge, G Del Zoppo… - The Lancet, 2012 - thelancet.com
Background Recombinant tissue plasminogen activator (rt-PA, alteplase) improved
functional outcome in patients treated soon after acute ischaemic stroke in randomised trials …

Thrombolysis for acute ischaemic stroke

JM Wardlaw, V Murray, E Berge… - Cochrane database of …, 2014 - cochranelibrary.com
Background Most strokes are due to blockage of an artery in the brain by a blood clot.
Prompt treatment with thrombolytic drugs can restore blood flow before major brain damage …

Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke

BCV Campbell, S Christensen, CR Levi, PM Desmond… - Stroke, 2012 - Am Heart Assoc
Background and Purpose—Perfusion imaging has the potential to select patients most likely
to respond to thrombolysis. We tested the correspondence of computed tomography …

Whole-brain CT perfusion to quantify acute ischemic penumbra and core

L Lin, A Bivard, V Krishnamurthy, CR Levi, MW Parsons - Radiology, 2016 - pubs.rsna.org
Purpose To validate the use of perfusion computed tomography (CT) with whole-brain
coverage to measure the ischemic penumbra and core and to compare its performance to …

Role of imaging in current acute ischemic stroke workflow for endovascular therapy

BK Menon, BCV Campbell, C Levi, M Goyal - Stroke, 2015 - Am Heart Assoc
Ischemic stroke is caused by a thrombus that blocks an intracranial artery. Brain tissue
beyond the blocked artery survives for a variable period of time because of blood and …

Intravenous thrombolysis for acute ischemic stroke within 3 hours versus between 3 and 4.5 hours of symptom onset

NT Cheng, AS Kim - The Neurohospitalist, 2015 - journals.sagepub.com
Data from randomized clinical trials have supported the safety and efficacy of intravenous
tissue-type plasminogen activator (IV tPA) for acute ischemic stroke when administered …

Machine learning–enabled automated determination of acute ischemic core from computed tomography angiography

SA Sheth, V Lopez-Rivera, A Barman, JC Grotta… - Stroke, 2019 - Am Heart Assoc
Background and Purpose—The availability of and expertise to interpret advanced
neuroimaging recommended in the guideline-based endovascular stroke therapy (EST) …