The method of generalized pairwise comparisons (GPC) is an extension of the well‐known
nonparametric Wilcoxon–Mann–Whitney test for comparing two groups of observations …

The win ratio, a recently proposed measure for comparing the benefit of two treatment
groups, allows ties in the data but ignores ties in the inference. In this article, we highlight …

Generalized pairwise comparisons and win statistics (ie, win ratio, win odds and net benefit)
are advantageous in analyzing and interpreting a composite of multiple outcomes in clinical …

Conventional analyses of a composite of multiple time‐to‐event outcomes use the time to
the first event. However, the first event may not be the most important outcome. To address …

The win ratio approach proposed by Pocock et al.(2012) has become a popular tool for
analyzing composite endpoints of death and non-fatal events like hospitalization. Its …

For composite outcomes whose components can be prioritized on clinical importance, the
win ratio, the net benefit and the win odds apply that order in comparing patients pairwise to …

The win ratio method has been increasingly applied in the design and analysis of clinical
trials. However, the win ratio method is a univariate approach that does not allow for …

Background The primary end point in most heart failure (HF) trials is a composite of time to a
first worsening HF event or cardiovascular death. Prevention of recurrent events and …

The restricted mean time in favor (RMT‐IF) of treatment is a nonparametric effect size for
complex life history data. It is defined as the net average time the treated spend in a more …

Target trial emulation applies design principles from randomised controlled trials to the
analysis of observational data for causal inference and is increasingly used within human …