Abstract Deficiency of ADA2 (DADA2) is the first molecularly described monogenic vasculitis
syndrome. DADA2 is caused by biallelic hypomorphic mutations in the ADA2 gene that …

The immune system plays a critical role in our health. No other component of human
physiology plays a decisive role in as diverse an array of maladies, from deadly diseases …

By diversifying antibody biological effector functions, class switch DNA recombination has a
central role in the maturation of the antibody response. Here we show that BCR-signalling …

Treatment of cultures with toll‐like receptor (TLR) ligands or cytokines has become a
popular approach to investigate astrocyte neuroinflammatory responses and to simulate the …

Several cancer immunotherapy approaches have been recently introduced into the clinics
and they have shown remarkable therapeutic potentials. The groundbreaking cancer …

Toll‐like receptors (TLR) play a central role in the initiation of the innate immune response to
pathogens. Upon recognition of molecular motifs specific for microbial molecules TLR …

Oxidant stress influences many cellular processes, including cell growth, differentiation, and
cell death. A well-recognized link between these processes and oxidant stress is via …

Antibody responses are classified according to whether B cells receive help from T cells—
that is, whether they are thymus-dependent (TD) responses or thymus-independent (TI) …

To optimize immunity to pathogens, B lymphocytes generate plasma cells with functionally
diverse antibody isotypes. By lineage tracing single cells within differentiating B cell clones …

Toll-like receptors (TLRs) play an important role in immune responses to pathogens by
transducing signals in innate immune cells in response to microbial products. TLRs are also …