The epilepsies are a heterogeneous group of disorders characterized by the propensity to
experience spontaneous recurrent seizures. Epilepsies can be genetic or acquired, and the …

Oxidative stress resulting from excessive free-radical release is likely implicated in the
initiation and progression of epilepsy. Therefore, antioxidant therapies aimed at reducing …

Mitochondria are central for various cellular processes that include ATP production,
intracellular Ca2+ signaling, and generation of reactive oxygen species. Neurons critically …

The roles of both neuroinflammation and oxidative stress in the pathophysiology of epilepsy
have begun to receive considerable attention in recent years. However, these concepts are …

Experts discussed the definition, natural history, pathologic features, pathogenesis,
electroclinical, neurophysiological, neuropsychological, structural and functional imaging …

Seizures are often the key manifestation of neurological diseases caused by pathogenic
mutations in 169 of the genes that have so far been identified to affect mitochondrial …

An insult to the brain (such as the first seizure) causes excitotoxicity, neuroinflammation, and
production of reactive oxygen/nitrogen species (ROS/RNS). ROS and RNS produced during …

Objective The full anticonvulsant effect of the ketogenic diet (KD) can require weeks to
develop in rats, suggesting that altered gene expression is involved. The KD typically is …

The ketogenic diet (KD) is a broadly effective treatment for medically refractory epilepsy.
Despite nearly a century of use, the mechanisms underlying its clinical efficacy remain …

Introduction: The brain is particularly susceptible to oxidative stress being the most
aerobically active organ in the body due to its high metabolic demands. There is evidence …