Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

Communication between the immune system and the central nervous system (CNS) is
exemplified by cross‐talk between glia and neurons shown to be essential for maintaining …

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease with heterogeneous
clinical presentations and course. MS is considered to be a T cell mediated disease but in …

The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

Multiple sclerosis (MS) is the prototypic inflammatory disease of the central nervous system
(CNS) characterized by multifocal areas of demyelination, axonal damage, activation of glial …

Autoantibody neuromyelitis optica-IgG (NMO-IgG) recognizing aquaporin-4 (AQP4) is
implicated as playing a central role in the physiopathology of NMO. The aim of this in vitro …

For decades, it has been widely believed that the blood–brain barrier (BBB) provides an
immune privileged environment in the central nervous system (CNS) by blocking peripheral …

Natural killer (NK) cells are innate lymphocytes that play a critical role in early host defense
against viruses. Through their cytolytic capacity and generation of cytokines and …

Regulatory T cells (Treg cells) play critical roles in the induction of peripheral tolerance to
self-and foreign antigens. Naturally occurring CD4+ CD25+ Treg cells, which …

Clonally expanded CD8+ T lymphocytes are present in multiple sclerosis lesions, as well as
in the cerebrospinal fluid of patients with multiple sclerosis. In experimental autoimmune …