WD40 repeat proteins: signalling scaffold with diverse functions
BP Jain, S Pandey - The protein journal, 2018 - Springer
The WD40 domain is one of the most abundant and interacting domains in the eukaryotic
genome. In proteins the WD domain folds into a β-propeller structure, providing a platform …
genome. In proteins the WD domain folds into a β-propeller structure, providing a platform …
The impact of mitotic errors on cell proliferation and tumorigenesis
MS Levine, AJ Holland - Genes & development, 2018 - genesdev.cshlp.org
Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …
Aneuploidy acts both oncogenically and as a tumor suppressor
BAA Weaver, AD Silk, C Montagna, P Verdier-Pinard… - Cancer cell, 2007 - cell.com
An abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells.
Boveri proposed nearly 100 years ago that aneuploidy causes tumorigenesis, but this has …
Boveri proposed nearly 100 years ago that aneuploidy causes tumorigenesis, but this has …
Does aneuploidy cause cancer?
BAA Weaver, DW Cleveland - Current opinion in cell biology, 2006 - Elsevier
Aneuploidy has been recognized as a common characteristic of cancer cells for> 100 years.
Aneuploidy frequently results from errors of the mitotic checkpoint, the major cell cycle …
Aneuploidy frequently results from errors of the mitotic checkpoint, the major cell cycle …
Aneuploidy and chromosomal instability in cancer: a jackpot to chaos
M Giam, G Rancati - Cell division, 2015 - Springer
Genomic instability (GIN) is a hallmark of cancer cells that facilitates the acquisition of
mutations conferring aggressive or drug-resistant phenotypes during cancer evolution …
mutations conferring aggressive or drug-resistant phenotypes during cancer evolution …
Living in CIN: mitotic infidelity and its consequences for tumor promotion and suppression
LC Funk, LM Zasadil, BA Weaver - Developmental cell, 2016 - cell.com
Errors in chromosome segregation during mitosis have been recognized as a hallmark of
tumor cells since the late 1800s, resulting in the long-standing hypothesis that mitotic …
tumor cells since the late 1800s, resulting in the long-standing hypothesis that mitotic …
Aneuploidy: instigator and inhibitor of tumorigenesis
BAA Weaver, DW Cleveland - Cancer research, 2007 - AACR
Aneuploidy, an aberrant chromosome number, has been recognized as a common
characteristic of cancer cells for more than 100 years and has been suggested as a cause of …
characteristic of cancer cells for more than 100 years and has been suggested as a cause of …
Diversity of WD-repeat proteins
TF Smith - The coronin family of proteins: Subcellular biochemistry, 2008 - Springer
The WD-repeat-containing proteins form a very large family that is diverse in both its function
and domain structure. Within all these proteins the WD-repeat domains are thought to have …
and domain structure. Within all these proteins the WD-repeat domains are thought to have …
[HTML][HTML] Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice
DJ Baker, KB Jeganathan, L Malureanu… - The Journal of cell …, 2006 - ncbi.nlm.nih.gov
Aging is a highly complex biological process that is believed to involve multiple
mechanisms. Mice that have small amounts of the mitotic checkpoint protein BubR1 age …
mechanisms. Mice that have small amounts of the mitotic checkpoint protein BubR1 age …
[HTML][HTML] Loss of spindle assembly checkpoint–mediated inhibition of Cdc20 promotes tumorigenesis in mice
M Li, X Fang, Z Wei, JP York, P Zhang - The Journal of cell biology, 2009 - ncbi.nlm.nih.gov
Genomic instability is a hallmark of human cancers. Spindle assembly checkpoint (SAC) is a
critical cellular mechanism that prevents chromosome missegregation and therefore …
critical cellular mechanism that prevents chromosome missegregation and therefore …