The WD40 domain is one of the most abundant and interacting domains in the eukaryotic
genome. In proteins the WD domain folds into a β-propeller structure, providing a platform …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

An abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells.
Boveri proposed nearly 100 years ago that aneuploidy causes tumorigenesis, but this has …

Aneuploidy has been recognized as a common characteristic of cancer cells for> 100 years.
Aneuploidy frequently results from errors of the mitotic checkpoint, the major cell cycle …

Genomic instability (GIN) is a hallmark of cancer cells that facilitates the acquisition of
mutations conferring aggressive or drug-resistant phenotypes during cancer evolution …

Errors in chromosome segregation during mitosis have been recognized as a hallmark of
tumor cells since the late 1800s, resulting in the long-standing hypothesis that mitotic …

Aneuploidy, an aberrant chromosome number, has been recognized as a common
characteristic of cancer cells for more than 100 years and has been suggested as a cause of …

The WD-repeat-containing proteins form a very large family that is diverse in both its function
and domain structure. Within all these proteins the WD-repeat domains are thought to have …

Aging is a highly complex biological process that is believed to involve multiple
mechanisms. Mice that have small amounts of the mitotic checkpoint protein BubR1 age …

Genomic instability is a hallmark of human cancers. Spindle assembly checkpoint (SAC) is a
critical cellular mechanism that prevents chromosome missegregation and therefore …