The release and absorption profile of an oral medication is influenced by the
physicochemical properties of the drug and its formulation, as well as by the anatomy and …

Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

The SLC22 transporter family consists of more than two dozen members, which are
expressed in the kidney, the liver, and other tissues. Evolutionary analysis indicates that …

The liver represents a major eliminating and detoxifying organ, determining exposure to
endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug …

Despite much progress in regulations to improve paediatric drug development, there
remains a significant need to develop better medications for children. For the design of oral …

Pain management in the pediatric population is complex for many reasons. Mild pain is
usually managed quite well with oral acetaminophen or ibuprofen. Situations involving more …

The role of membrane transporters on pharmacokinetics (PKs), drug–drug interactions
(DDIs), pharmacodynamics (PDs), and toxicity of drugs has been broadly recognized …

Protein expression of major hepatic uptake and efflux drug transporters in human pediatric
(n= 69) and adult (n= 41) livers was quantified by liquid chromatography/tandem mass …

Following a request from the European Commission to EFSA, the EFSA Scientific Committee
(SC) prepared a guidance for the risk assessment of substances present in food intended for …

Population pharmacokinetic (popPK) modeling was used to characterize the PK profile of
the oral Janus kinase (JAK) 1/JAK2 inhibitor, baricitinib, in 18 patients with Mendelian …