Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …
Microglia: agents of the CNS pro-inflammatory response
JA Rodríguez-Gómez, E Kavanagh… - Cells, 2020 - mdpi.com
The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …
pathogenesis of several neurodegenerative diseases. Though the research of microglia …
Microglia and inflammatory responses in diabetic retinopathy
UM Kinuthia, A Wolf, T Langmann - Frontiers in immunology, 2020 - frontiersin.org
Diabetic retinopathy is a vision-threatening disease affecting neurons and microvasculature
of the retina. The development of this disease is associated with the action of inflammatory …
of the retina. The development of this disease is associated with the action of inflammatory …
Cell type-specific inference of differential expression in spatial transcriptomics
A central problem in spatial transcriptomics is detecting differentially expressed (DE) genes
within cell types across tissue context. Challenges to learning DE include changing cell type …
within cell types across tissue context. Challenges to learning DE include changing cell type …
Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study
MM Etter, TA Martins, L Kulsvehagen… - Nature …, 2022 - nature.com
Growing evidence links COVID-19 with acute and long-term neurological dysfunction.
However, the pathophysiological mechanisms resulting in central nervous system …
However, the pathophysiological mechanisms resulting in central nervous system …
Comparative single-cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution
Enhanced cognitive function in humans is hypothesized to result from cortical expansion
and increased cellular diversity. However, the mechanisms that drive these phenotypic …
and increased cellular diversity. However, the mechanisms that drive these phenotypic …
Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination
Background Emerging RNA viruses that target the central nervous system (CNS) lead to
cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus …
cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus …
Dysregulation of GABAergic signaling in neurodevelomental disorders: targeting cation-chloride co-transporters to re-establish a proper E/I balance
The construction of the brain relies on a series of well-defined genetically and experience-or
activity-dependent mechanisms which allow to adapt to the external environment. Disruption …
activity-dependent mechanisms which allow to adapt to the external environment. Disruption …
Increased macrophages and C1qA, C3, C4 transcripts in the midbrain of people with schizophrenia
TD Purves-Tyson, K Robinson, AM Brown… - Frontiers in …, 2020 - frontiersin.org
Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a
dopamine neuron-rich region associated with schizophrenia symptoms. In fact, half of …
dopamine neuron-rich region associated with schizophrenia symptoms. In fact, half of …
Immune response in neurological pathology: emerging role of central and peripheral immune crosstalk
Neuroinflammation is a key component of neurological disorders and is an important
therapeutic target; however, immunotherapies have been largely unsuccessful. In cases …
therapeutic target; however, immunotherapies have been largely unsuccessful. In cases …