[HTML][HTML] Host-directed therapies for bacterial and viral infections

SHE Kaufmann, A Dorhoi, RS Hotchkiss… - Nature reviews Drug …, 2018 - nature.com
Despite the recent increase in the development of antivirals and antibiotics, antimicrobial
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …

Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen

A Maitra, T Munshi, J Healy, LT Martin… - FEMS microbiology …, 2019 - academic.oup.com
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …

Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity

JD Guzman - Molecules, 2014 - mdpi.com
Antimicrobial natural preparations involving cinnamon, storax and propolis have been long
used topically for treating infections. Cinnamic acids and related molecules are partly …

The changing paradigm of drug-resistant tuberculosis treatment: successes, pitfalls, and future perspectives

N Dookie, SL Ngema, R Perumal… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Drug-resistant tuberculosis (DR-TB) remains a global crisis due to the increasing incidence
of drug-resistant forms of the disease, gaps in detection and prevention, models of care, and …

Tuberculosis treatment and management—an update on treatment regimens, trials, new drugs, and adjunct therapies

A Zumla, J Chakaya, R Centis, L D'Ambrosio… - The Lancet …, 2015 - thelancet.com
WHO estimates that 9 million people developed active tuberculosis in 2013 and 1· 5 million
people died from it. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) …

New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects

AI Zumla, SH Gillespie, M Hoelscher… - The Lancet infectious …, 2014 - thelancet.com
About 1· 3 million people died of tuberculosis in 2012, despite availability of effective drug
treatment. Barriers to improvements in outcomes include long treatment duration (resulting …

Totally drug‐resistant tuberculosis and adjunct therapies

SK Parida, R Axelsson‐Robertson… - Journal of internal …, 2015 - Wiley Online Library
The first cases of totally drug‐resistant (TDR) tuberculosis (TB) were reported in Italy 10
years ago; more recently, cases have also been reported in Iran, India and South Africa …

Progress in tuberculosis vaccine development and host-directed therapies—a state of the art review

SHE Kaufmann, C Lange, M Rao, KN Balaji… - The Lancet …, 2014 - thelancet.com
Tuberculosis continues to kill 1· 4 million people annually. During the past 5 years, an
alarming increase in the number of patients with multidrug-resistant tuberculosis and …

Comprehensive review on mechanism of action, resistance and evolution of antimycobacterial drugs

A Chauhan, M Kumar, A Kumar, K Kanchan - Life sciences, 2021 - Elsevier
Tuberculosis is one of the deadliest infectious diseases existing in the world since ancient
times and still possesses serious threat across the globe. Each year the number of cases …

Potential repurposed drug candidates for tuberculosis treatment: progress and update of drugs identified in over a decade

K Sharma, F Ahmed, T Sharma, A Grover… - ACS …, 2023 - ACS Publications
The devastating impact of Tuberculosis (TB) has been a menace to mankind for decades.
The World Health Organization (WHO) End TB Strategy aims to reduce TB mortality up to …