Hepatitis B virus (HBV) infection causes chronic hepatitis and has long term complications.
Individuals ever infected with HBV are at risk of viral reactivation under certain …

During hepatitis B virus (HBV) infection, the presence of HBV-specific antibody producing B
cells and functional HBV-specific T cells (with helper or cytotoxic effects) ultimately …

To identify disease-relevant T cell receptors (TCRs) with shared antigen specificity, we
analyzed 778,938 TCRβ chain sequences from 178 non-small cell lung cancer patients …

Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …

CD8+ T cells are key antiviral effectors against hepatitis B virus (HBV), yet their number and
function can be compromised in chronic infections. Preclinical HBV models displaying CD8+ …

More than 500 million people worldwide are persistently infected with the hepatitis B virus
(HBV) and/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease …

Although the CD4+-and CD8+-T-cell responses to the hepatitis B virus (HBV) are thought to
be crucial for the control of HBV infection, the relative contribution of each T-cell subset as …

Dysfunctional CD8+ T cells present in chronic virus infections can express programmed
death 1 (PD-1) molecules, and the inhibition of the engagement of PD-1 with its ligand (PD …

The adaptive immune response is thought to be responsible for viral clearance and disease
pathogenesis during hepatitis B virus infection. It is generally acknowledged that the …

Hepatitis B virus (HBV) is a noncytopathic virus, and the recognition of infected hepatocytes
by HBV-specific CD8 cells has been assumed to be the central mechanism causing both …