Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
Insulin stimulates the translocation of the glucose transporter GLUT4 from intracellular
vesicles to the plasma membrane. In the present study we have conducted a comprehensive …
vesicles to the plasma membrane. In the present study we have conducted a comprehensive …
Functional Studies of Akt Isoform Specificity in Skeletal Muscle in Vivo; Maintained Insulin Sensitivity Despite Reduced Insulin Receptor Substrate-1 Expression
ME Cleasby, TA Reinten, GJ Cooney… - Molecular …, 2007 - academic.oup.com
The phosphoinositide 3-kinase/Akt pathway is thought to be essential for normal insulin
action and glucose metabolism in skeletal muscle and has been shown to be dysregulated …
action and glucose metabolism in skeletal muscle and has been shown to be dysregulated …
Development of RNA interference–based therapeutics and application of multi-target small interfering RNAs
T Li, M Wu, YY Zhu, J Chen, L Chen - nucleic acid therapeutics, 2014 - liebertpub.com
RNA interference (RNAi) has been proven in recent years to be a newly advanced and
powerful tool for development of therapeutic agents toward various unmet medical needs …
powerful tool for development of therapeutic agents toward various unmet medical needs …
[HTML][HTML] ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation
J Stöckli, A Zadoorian, KC Cooke, V Deshpande… - Molecular …, 2019 - Elsevier
Objective Insulin suppresses adipose tissue lipolysis after a meal, playing a key role in
metabolic homeostasis. This is mediated via the kinase Akt and its substrate …
metabolic homeostasis. This is mediated via the kinase Akt and its substrate …
[HTML][HTML] Multi-target siRNA: Therapeutic strategy for hepatocellular carcinoma
T Li, Y Xue, G Wang, T Gu, Y Li, YY Zhu… - Journal of Cancer, 2016 - ncbi.nlm.nih.gov
Multiple targets RNAi strategy is a preferred way to treat multigenic diseases, especially
cancers. In the study, multi-target siRNAs were designed to inhibit NET-1, EMS1 and VEGF …
cancers. In the study, multi-target siRNAs were designed to inhibit NET-1, EMS1 and VEGF …
Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes
ME Cleasby, JR Davey, TA Reinten, MW Graham… - Diabetes, 2005 - Am Diabetes Assoc
Analysis of conventional germ-line or tissue-specific gene manipulation in vivo is potentially
confounded by developmental adaptation of animal physiology. We aimed to adapt the …
confounded by developmental adaptation of animal physiology. We aimed to adapt the …
Tissue-specific delivery of oligonucleotides
From the initial discovery of short-interfering RNA (siRNA) and antisense oligonucleotides
for specific gene knockdown at the posttranscriptional level to the current CRISPR-Cas9 …
for specific gene knockdown at the posttranscriptional level to the current CRISPR-Cas9 …
Defining transgene insertion sites and off-target effects of homology-based gene silencing informs the application of functional genomics tools in Phytophthora …
AL Vu, W Leesutthiphonchai… - Molecular Plant …, 2019 - Am Phytopath Society
DNA transformation and homology-based transcriptional silencing are frequently used to
assess gene function in Phytophthora spp. Since unplanned side-effects of these tools are …
assess gene function in Phytophthora spp. Since unplanned side-effects of these tools are …
多靶向RNA 干扰技术在基因治疗中的应用与前景
薛玉文， 李铁军， 周家名， 陈莉 - 中国生物工程杂志, 2015 - manu60.magtech.com.cn
RNA 干扰(RNA interference, RNAi) 通过转录后基因沉默效应特异性抑制靶基因的表达,
其沉默机制的高效性, 特异性及稳定性使这项技术成为生物医学领域研究基因治疗的重要工具 …
其沉默机制的高效性, 特异性及稳定性使这项技术成为生物医学领域研究基因治疗的重要工具 …
Interfering RNA with multi-targets for efficient gene suppression in HCC cells
T Li, YY Zhu, Y Ji, S Zhou - International Journal of …, 2018 - spandidos-publications.com
RNA interference (RNAi) technology has been widely used in therapeutics development,
especially multiple targeted RNAi strategy, which is a better method for multiple gene …
especially multiple targeted RNAi strategy, which is a better method for multiple gene …